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Filtered Search Results
Medchemexpress LLC Rocaglamide | 84573-16-0 | 505.56 | 50 MG
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Rocaglamide is isolated from the genus Aglaia and can be used for coughs, injuries, asthma, and inflammatory skin diseases. It is a potent inhibitor of NF-κB activation in T-cells and a selective heat shock factor 1 (HSF1) activation inhibitor with an IC50 of ~50 nM. Rocaglamide also inhibits the function of the translation initiation factor eIF4A and exhibits anticancer properties in leukemia.
- Isolated from the genus Aglaia.
- Can be used for coughs, injuries, asthma, and inflammatory skin diseases.
- Potent inhibitor of NF-κB activation in T-cells.
- Potent and selective heat shock factor 1 (HSF1) activation inhibitor.
- Inhibits the function of the translation initiation factor eIF4A.
- Has anticancer properties in leukemia.
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Medchemexpress LLC Prexasertib (dimesylate) | 1234015-58-7 | 98.9% | 557.60 | 5 MG
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Prexasertib dimesylate is a selective, ATP-competitive second-generation checkpoint kinase 1 (CHK1) inhibitor with a Ki of 0.9 nM and an IC50 of <1 nM. It also inhibits CHK2 (IC50=8 nM) and RSK1 (IC50=9 nM). This compound induces double-stranded DNA breakage and replication catastrophe, leading to apoptosis, and demonstrates potent anti-tumor activity.
- Selective, ATP-competitive CHK1 inhibitor
- Inhibits CHK1 (Ki 0.9 nM, IC50 <1 nM), CHK2, and RSK1
- Induces double-stranded DNA breakage and replication catastrophe
- Leads to apoptosis and potent anti-tumor activity
- Inhibits MELK, SIK, BRSK2, and ARK5
- Requires CDC25A and CDK2 for DNA damage
- Causes DNA damage during S-phase
- Inhibits CHK1 and CHK2 autophosphorylation
- Induces cell-cycle shift with H2AX phosphorylation
- Triggers chromosomal fragmentation and replication stress
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MICROSOLV TECHNOLOGY CORPORATION DI-AD SINGLE .030 X 500
502269791 DI-AD SINGLE .030 X 500
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Aobchem 2-Iodo-1 3-dimethoxybenzene | ≥97% | CAS 16932-44-8 | C8H9IO2 | 25g
2-Iodo-1 3-dimethoxybenzene | ≥97% | CAS 16932-44-8 | C8H9IO2 | 25g
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Medchemexpress LLC HY-12067 5mg Medchemexpress, R406 CAS:841290-81-1 Purity:>98%
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Medchemexpress, HY-12067 5mg R406 CAS:841290-81-1 R406 is a competitive Syk inhibitor for ATP binding with a Ki of 30 nM, potently inhibits Syk kinase activity in vitro with an IC50 of 41 nM, measured at an ATP concentration corresponding to its Km value. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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Medchemexpress LLC HY-14885 100mg , Eliglustat Genz 99067 CAS:491833-29-5 Purity:98%
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Medchemexpress, HY-14885 100mg Eliglustat Genz 99067 CAS:491833-29-5 Formula:C23H36N2O4 IC50: 24 nM (glucocerebroside synthase) Purity:98% Eliglustat is an specific, potent and orally active glucocerebroside synthase inhibitor with an IC 50 of 24 nM. Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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Medchemexpress LLC HY-B0195 10mg Medchemexpress, Tranilast CAS:53902-12-8 Purity:>98%
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Medchemexpress, HY-B0195 10mg Tranilast CAS:53902-12-8 Tranilast (MK-341) acts as an anti-atopic agent. Tranilast suppresses production of prostaglandin D2 (PGD2, IC50= 0.1 mM). Tranilast sodium exhibits anti-inflammatory and immunomodulatory effects. Tranilast sodium antagonizes angiotensin II and inhibits its biological effects in vascular smooth muscle cells[2]. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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Medchemexpress LLC HY-10917 1g , GW2580 CAS:870483-87-7 Purity:98%
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Medchemexpress, HY-10917 1g GW2580 CAS:870483-87-7 Formula:C20H22N4O3 IC50: 30 nM (c-FMS) Purity:98% GW2580 is a selective CSF-1R inhibitor for c-FMS with IC 50 of 30 nM, and shows 150- to 500-fold selective compared to b-Raf, CDK4, c-KIT, c-SRC, EGFR, ERBB2/4, ERK2, FLT-3, GSK3, ITK, JAK2, etc. Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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Medchemexpress LLC HY-15392 10mg , Chroman 1 ROCK-II inhibitor CAS:1273579-40-0 Purity:98%
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Medchemexpress, HY-15392 10mg Chroman 1 ROCK-II inhibitor CAS:1273579-40-0 Formula:C24H28N4O4 IC50: < 1 nM (ROCK2) Purity:98% Chroman 1 is a highly potent ROCK2 inhibitor, with an IC 50 of < 1 nM. Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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Medchemexpress LLC HY-13757A 5g , Tamoxifen ICI47699;Z-Tamoxifen;trans-Tamoxifen CAS:10540-29-1 Purity:98%
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Medchemexpress, HY-13757A 5g Tamoxifen ICI47699;Z-Tamoxifen;trans-Tamoxifen CAS:10540-29-1 Formula:C26H29NO Estrogen receptor Purity:98% Tamoxifen is an antiestrogen by inhibiting the binding of estrogen to estrogen receptors . Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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Aobchem 4-Ethynyl-1 2-dimethoxybenzene | ≥95% | CAS 4302-52-7 | C10H10O2 | 5g
4-Ethynyl-1 2-dimethoxybenzene | ≥95% | CAS 4302-52-7 | C10H10O2 | 5g
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Medchemexpress LLC HY-16901A 5mg Medchemexpress, Firsocostat S enantiomer CAS: Purity:>98%
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Medchemexpress, HY-16901A 5mg Firsocostat S enantiomer CAS: Firsocostat S enantiomer (ND-630 S enantiomer) is the less active S enantiomer of Firsocostat. Firsocostat is an acetyl-CoA carboxylase (ACC) inhibitor. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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Medchemexpress LLC MAL-VC-PAB-DM1 10 mg
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MAL-VC-PAB-DM1 10MG
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Medchemexpress LLC HY-101312 5mg Medchemexpress, Cilostamide CAS:68550-75-4 Purity:>98%
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Medchemexpress, HY-101312 5mg Cilostamide CAS:68550-75-4 Cilostamide is a selective and potent PDE3 inhibitor, with IC 50 s of 27 nM and 50 nM for PDE3A and PDE3B, respectively, and has antithrombotic and anti-intimal hyperplastic activity. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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Medchemexpress LLC HY-50697 100mg Medchemexpress, A-740003 CAS:861393-28-4 Purity:98%
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Medchemexpress,HY-50697 100mg A-740003 CAS:861393-28-4 Formula:C26H30N6O3 A-740003 is a potent, selective and competitive P2X7 receptor antagonist with IC50 values are 18 and 40 nM for rat and human P2X7 receptors, respectively. Purity:98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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